A new facile synthesis of shikalkin

作者：Lu Qun^*; Tang Hao Lun; Shao Yan Qiang; Cai Jun Chao

来源：Chinese Chemical Letters, 2008, 19(2): 172-174.

DOI：10.1016/j.cclet.2007.11.031

• synthesis
• shikalkin
• epoxides

A short and convergent approach for the synthesis of shikalkin (dl-shikonin) is presented. Stobbe reaction was employed to construct the aromatic skeleton 6. This is followed by a practical method to prepare the key epoxides 9 from aldehydes 8 in high yield. Finally, shikalkin is achieved by Grignard reaction and oxidation.

• 出版日期2008-2
• 单位中国科学院上海药物研究所; 西南交通大学