Antioxidant activity of purified ulvan in hyperlipidemic mice

作者：Li, Weida; Jiang, Nanfang; Li, Bingxi; Wan, Minghui; Chang, Xintao; Liu, Hui; Zhang, Li; Yin, Shupeng; Qi, Huimin^*; Liu, Shunmei^*

来源：International Journal of Biological Macromolecules, 2018, 113: 971-975.

DOI：10.1016/j.ijbiomac.2018.02.104

• Polysaccharide
• Oxidative damage
• Ulva pertusa

Several studies have reported that ulvan from the alga Ulva pertusa (Chlorophyta) exhibits substantial antioxidant and antihyperlipidemic activities; however, which group of heteropolysaccharides play roles in these activities remains unknown. In this study, three purified ulvan (PU1, PU2 and PU3) have been obtained by DEAE-Sepharose fast-flow column. The antioxidant activity was detected via the model of hyperlipidemic Kunming mice, including malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in liver. PU3, which possessed the highest uronic acid content (24.09%) and sulfate content (23.99%) as well as the lowest average molecular weight (83,094 Da), exhibited the stronger antioxidant activity than other examples. It significantly decreased MDA (29.2%; P<0.05), increased SOD (36.4%; P<0.05) and CAT (43.6%; P<0.05) compared with hyperlipidemia group. In conclusion, PU3 may be potential sources of natural antioxidant to protecting against the liver damage of oxidative stress induced by cholesterol-rich diet.

• 出版日期2018-7-1
• 单位潍坊医学院