Anti-HIV 1 Activity of Xanthones from the Bark of Mammea harmandii

作者：Liangsakul Ponsiri; Kuhakarn Chutima; Hongthong Sakchai; Jariyawat Surawat; Suksen Kanoknetr; Akkarawongsapat Radeekorn; Limthongkul Jitra; Napaswad Chanita; Reutrakul Vichai^*

来源：Natural Product Communications, 2018, 13(1): 53-56.

• Mammea harmandii
• Guttiferae
• Xanthone glycoside
• Astilbin
• Anti-HIV

A new xanthone glycoside 1 together with four known flavonoid derivatives, astilbin (2), neoastilbin (3), isoastilbin (4), and epicatechin (5) were isolated from the ethyl acetate fraction partitioned from the methanol extract of the bark of Mammea harmandii. The chemical structures of all isolated compounds were established on the basis of their spectroscopic data. Compound 1 exhibited selective significant inhibitory activity in the anti-syncytium assay with an EC50 value of 11.44 mu M (SI = 14.03) while it was found inactive against HIV 1 reverse transcriptase as well as cytotoxic activity.

• 出版日期2018-1