Acid-catalyzed reactions of 3-hydroxy-2-oxindoles with electron-rich substrates: synthesis of 2-oxindoles with all-carbon quaternary center

作者：Kinthada Lakshmana K; Ghosh Santanu; De Subhadip; Bhunia Subhajit; Dey Dhananjay; Bisai Alakesh^*

来源：Organic and Biomolecular Chemistry, 2013, 11(40): 6984-6993.

DOI：10.1039/c3ob41482e

A Lewis acid catalyzed reaction of in situ generated 2H-indol-2-one (9) with various 2 pi and other electron-rich substrates has been developed. A variety of electron-rich substrates such as allyl/methallyl-trimethylsilane, phenylacetylene, styrenes, acetophenone, and indoles have been used. The methodology provides a straightforward approach for the synthesis of 2-oxindoles with an all-carbon quaternary center at the pseudobenzylic position.

• 出版日期2013-10-28