MicroRNA-520g induces epithelial-mesenchymal transition and promotes metastasis of hepatocellular carcinoma by targeting SMAD7

作者：Kan, Heping; Guo, Wenbin; Huang, Yuqi^*; Liu, Dingli

来源：FEBS LETTERS, 2015, 589(1): 102-109.

DOI：10.1016/j.febslet.2014.11.031

• MicroRNA-520g
• Hepatocellular carcinoma
• Epithelial-mesenchymal transition
• SMAD family member 7
• Cancer metastasis

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Aberrant expression of miRNAs contributes to HCC development. Here, we observed elevated miR-520g expression in tumor samples from HCC patients with relapse and metastasis, and this high miR-520g expression was correlated with poor survival. Through gain-and loss-of-function studies, miR-520g was demonstrated to facilitate HCC cell migration, invasion and epithelial-mesenchymal transition (EMT). SMAD7 was identified as a direct target of miR-520g. Accordingly, we conclude that high miR-520g expression promotes HCC cell mobility and EMT by targeting SMAD7, and this is correlated with reduced survival in HCC patients.

• 出版日期2015-1-2
• 单位南方医科大学