Design and synthesis of beta-methoxyacrylate analogues via click chemistry and biological evaluations

作者：Chen Hao; Taylor Janet L^*; Abrams Suzanne R

来源：Bioorganic & Medicinal Chemistry Letters, 2007, 17(7): 1979-1983.

DOI：10.1016/j.bmcl.2007.01.021

• antifungal
• strobulirin natural products
• beta-methoxylacrylates
• click chemistry

A library of potential antifungal triazole-modified P-methoxyacrylate analogues was designed and synthesized via a Cu(I)-catalyzed 1,3-dipolar alkyne-azide coupling reaction or 'click chemistry'. Subsequent biological screening revealed that some compounds displayed low to moderate antifungal activity toward pathogenic fungi and low phytotoxicity.

• 出版日期2007-4-1