Differential Diagnostic Performance of Rose Bengal Score Test in Sjogren's Syndrome Patients

作者：Knezovic Igor^*; Alajbeg Ivan; Karlovic Dalibor; Pavan Josip; Vrkic Nada; Biscan Ana

来源：Collegium Antropologicum, 2011, 35(4): 1105-1113.

• Rose Bengal
• Sjogren's syndrome
• Keratokonjunctivitis Sicca
• Xerostomia
• salivary gland diseases
• Tear Break-Up Time test
• ophthalmologic questionnaire
• labial gland biopsy

Aim of the study was to evaluate the diagnostic performance of the Rose Bengal score test for Sjogren's syndrome (SS), and to explore differences between other tests and examinations. All participants were examined, including (but not limited to) unstimulated (UWS) and stimulated (SWS) whole saliva, labial gland biopsy (LGB or focus score), ophthalmologic questionnaire (ocular surface disease index OSDI) and objective tests: Schirmer test 1 (Sch.1), Schirmer test 2 (Sch.2), Tear Break-up Time (TB UT) test and Rose Bengal score (RBS). Data were analyzed using Mann Whitney U-test, Receiver Operating Characteristic analysis, with specificity and sensitivity calculations and Spearman's correlation test. ROC curves showed a poor diagnostic performance of TBUT and OSDL Sch.1, Sch.2 and LGB all exhibited a high diagnostic performance. RBS exhibited the best performance (sensitivity 100,00; specificity 100,00; AUC 1,000). Study reveals the scarce reliability of TBUT, OSDI and Sch.1, and emphasizes RBS as the test of choice in the SS diagnosis.

• 出版日期2011-12