A semi-adaptive control approach to closed-loop medication infusion

作者：Jin Xin; Kim Chang Sei; Dumont Guy A; Ansermino J Mark; Hahn Jin Oh^*

来源：International Journal of Adaptive Control and Signal Processing, 2017, 31(2): 240-254.

DOI：10.1002/acs.2696

• semi-adaptive control
• medication infusion
• direct dynamic dose-response model
• model-reference adaptive control
• composite adaptive control

This paper presents a semi-adaptive control approach to closed-loop medication infusion problems. The rationale underlying this approach is to design a controller that can adapt model parameters with a large impact on the model's fidelity while fixing the remaining parameters at nominal values. In this paper, a control-oriented model for this purpose is derived via system identification and sensitivity analysis of a low-order model capturing the direct dose-response relationship Using the model thus derived, a model-reference adaptive controller and a composite adaptive controller are designed and compared with each other. In-silico simulation results using remifentanil's effect on respiratory rate as an example indicate that both controllers can regulate the output at commanded set points.

• 出版日期2017-2