Antitumour activity of abiraterone acetate against metastatic castration-resistant prostate cancer progressing after docetaxel and enzalutamide (MDV3100)

作者：Loriot, Y.^*; Bianchini, D.; Ileana, E.; Sandhu, S.; Patrikidou, A.; Pezaro, C.; Albiges, L.; Attard, G.; Fizazi, K.; De Bono, J. S.; Massard, C.

来源：Annals of Oncology, 2013, 24(7): 1807-1812.

DOI：10.1093/annonc/mdt136

• CRPC
• enzalutamide
• abiraterone
• hormonal manipulations

Background: Androgen receptor (AR) signalling remains critically important in metastatic castration-resistant prostate cancer (mCRPC) as confirmed by recent phase III trials, showing a survival advantage for abiraterone acetate and enzalutamide (MDV3100). The antitumour activity of abiraterone and prednisolone in patients pre-treated with enzalutamide is as yet unknown. @@@ Patients and methods: We investigated the antitumour activity of abiraterone and prednisolone in patients with mCRPC who had progressed following treatment with docetaxel (Taxotere) and enzalutamide. Clinical data were retrospectively analysed for prostate-specific antigen (PSA) and RECIST responses, clinical benefit and survival. @@@ Results: Thirty-eight patients were included in the analysis. The median age was 71 years (range 52-84); metastatic sites included bone disease in 37 patients (97%), lymph nodes in 15 patients (39%) and visceral disease in 10 patients (26%). Abiraterone was well tolerated. Three patients (8%) attained a PSA response, defined as >= 50% decline in PSA confirmed after >= 4 weeks, while seven patients (18%) had a >= 30% PSA decline. The median progression-free survival (PFS) was 2.7 months (95% Cl 2.3-4.1). Of the 12 patients assessable radiologically, only 1 (8%) attained a confirmed partial response. @@@ Conclusion: Abiraterone and prednisolone have modest antitumour activities in patients with mCRPC pretreated with docetaxel and enzalutamide.

• 出版日期2013-7