Different evolutionary patterns of classical swine fever virus envelope proteins

作者：Li, Yan^*; Yang, Zexiao; Zhang, Mingwang

来源：Canadian Journal of Microbiology, 2016, 62(3): 210-219.

DOI：10.1139/cjm-2015-0709

• classical swine fever virus
• envelope proteins
• adaptive diversification
• different patterns

Classical swine fever virus (CSFV) is the causative agent of classical swine fever, which is a highly contagious disease of the domestic pig as well as wild boar. The proteins E-rns, E1, and E2 are components of the viral envelope membrane. They are also implicated in virus attachment and entry, replication, and (or) anti-immune response. Here, we studied the genetic variations of these envelope proteins in the evolution of CSFV. The results reveal that the envelope proteins underwent different evolutionary fates. In E-rns and E1, but not E2, a number of amino acid sites experienced functional divergence. Furthermore, the diversification in E-rns and E1 was generally episodic because the divergence-related changes of E1 only occurred with the separation of 2 major groups of CSFV and that of E-rns took place with the division of 1 major group. The major divergence-related sites of Erns are located on one of the substrate-binding regions of the RNase domain and C-terminal extension. These functional domains have been reported to block activation of the innate immune system and attachment and entry into host cells, respectively. Our results may shed some light on the divergent roles of the envelope proteins.

• 出版日期2016-3
• 单位四川农业大学