Anti-Metastatic and Anti-Angiogenic Activities of Core-Shell SiO2@LDH Loaded with Etoposide in Non-Small Cell Lung Cancer

作者：Zhu, Yanjing; Zhu, Rongrong^*; Wang, Mei; Wu, Bin; He, Xiaolie; Qian, Yechang^*; Wang, Shilong^*

来源：Advanced Science, 2016, 3(11): 1600229.

DOI：10.1002/advs.201600229

• DOUBLE HYDROXIDE NANOPARTICLES
• LAYERED DOUBLE HYDROXIDES
• BREAST-CANCER
• GROWTH-FACTOR
• SURFACE-AREA
• TUMOR-GROWTH
• METASTASIS
• THERAPY
• DRUGS
• MICROTUBULES

Currently, nanoparticles have gained a great attention in the anti-tumor research area. However, to date, studies on the anti-metastasis action of core-shell SiO2@LDH (LDH: layered double hydroxide) nanoparticles remain untouched. Two emerging aspects considered are establishing research on the controlling delivery effect of SiO2@LDH combined with anti-cancer medicine from a new perspective. The fine properties synthetic SiO2@LDH-VP16 (VP16: etoposide) are practiced to exhibit the nanoparticle's suppression on migration and invasion of non-small cell lung cancer (NSCLC). Both in vitro and in vivo inspection shows that SiO2@LDH can help VP16 better function as an anti-metastasis agent. On the other hand, anti-angiogenic efficiency, co-localization, as well as western blot are investigated to explain the possible mechanism. A clear mergence of SiO2@LDH-VP16 and cytomembrane/microtubule may be observed from co-location images. Results offer evidence that SiO2@LDH-VP16 plays positions on cytomembrane and microtubules. It efficiently inhibits metastasis on NSCLC by reducing vascularization, and eliciting depression of the PI3K-AKT and FAK-Paxillin signaling pathways. SiO2@LDH-VP16, the overall particle morphology, and function on anti-metastasis and anti-angiogenic may be tuned to give new opportunities for novel strategies for cancer therapy.

• 出版日期2016-11
• 单位同济大学