Systematic evaluation of TCF7L2 rs12255372 polymorphism and the gestational diabetes mellitus risk

作者：SHEN Chao-yan; FAN Jie-hua; CHEN Dan-dan; PENG Ling-xiang; CHEN Zai-ming; LU Xue-ping; QIN Xiu-mei; WANG Yu-chun; QIN Ji-xiu; WEN Ai-zhen; TANG Ling-fang; SHI Qing-feng; YU Hong-ping; YU Xiang-yuan

来源：现代预防医学, 2017, 44(9).

• TCF7L2 gene
• Polymorphism
• Gestational diabetes mellitus
• Risk of disease

Objective To investigate the association between the polymorphism of transcription factor 7-like 2 (TCF7L2) gene polymorphism rs12255372 G ＞ T and the risk of gestational diabetes mellitus(GDM).Methods Case-control studies on the association between rs12255372 G ＞ T polymorphism on GDM risk were searched by using the NCBI PubMed,CNKI and Wanfang database before September 2016.Stata12.0 software was adopted to detect the publication bias and heterogeneity across the included study,and the combined OR with corresponding 95％ CI was used to assessing rs12255372 and GDM risk.Results According to the inclusion and exclusion criteria,totally 9 studies with 5778 subjects were included.Meta-analysis showed that comparing with G allele,rs12255372 T allele could significantly increase the risk of GDM,and the combined OR and corresponding 95 ％ CI were 1.28 (1.16-1.40) in overall.Subgroup analysis by ethnic showed that the combined OR and corresponding 95％ CI were 1.29 (1.15 ～ 1.45) in Caucasians and 1.25 (1.05 ～ 1.48) in Asians.Genotype analysis showed that rs12255372 G ＞ T was significantly associated with the risk of GDM in the dominant model.Compared with the GG genotype,the GT + TT genotype carriers had a significantly higher risk of GDM,and the combined OR and 95％ CI were 1.35 (1.20 ～ 1.53) in overall,and 1.39 (1.20 ～ 1.62) in Caucasians and 1.28 (1.04 ～ 1.58) in Asians.Conclusion TCF7L2 rs12255372 G ＞ T polymorphism are closely related to the risk of GDM,and G(T variant may increase the GDM risk in pregnant women.

• 出版日期2017
• 单位桂林医学院