Amniotic fluid urocortin-1 concentrations for the prediction of preterm delivery

作者：Karaer Abdullah^*; Celik Ebru; Celik Onder; Simsek Omer Yavuz; Ozerol Ibrahim Halil; Yilmaz Ercan; Turkcuoglu Ilgin; Duz Senem Arda

来源：Journal of Obstetrics and Gynaecology Research, 2013, 39(7): 1236-1241.

DOI：10.1111/jog.12054

• amniotic fluid
• preterm delivery
• urocortin-1

Aim The aim of this study was to analyze whether urocortin-1 concentration in midtrimester amniotic fluid could serve as an indicative marker of preterm labor. Material and Methods A retrospective cohort study was conducted. Urocortin-1 concentrations in midtrimester amniotic fluid were measured in 22 pregnant women with preterm deliveries and 45 women who delivered at term using enzyme-linked immunosorbent assay. Results The median amniotic fluid urocortin-1 concentration was significantly lower in the women with preterm birth (40.06pg/mL; range, 13.77-67.58pg/mL) than in the women who gave birth at term (49.56pg/mL; range, 26.25-175.9pg/mL; P=0.022). The result of receiver-operator curve analysis indicates that an amniotic fluid urocortin-1 concentration57.88pg/mL had an area under the curve of 0.673 (95% confidence interval, 0.55-0.78; P=0.01) with a sensitivity of 81.8%, specificity of 40.0%, positive predictive value of 40%, and a negative predictive value of 82% in identifying which of the patients subsequently delivered prematurely. Conclusions These results suggest that low urocortin-1 concentration in midtrimester amniotic fluid could be used as an indicative marker of preterm birth.

• 出版日期2013-7