Antiedematogenic activity and phytochemical composition of preparations from Echinodorus grandiflorus leaves

作者：Garcia Eliana de Faria; de Oliveira Mariana Assiria; Godin Adriana Martins; Ferreira Wallace Carvalho; Silva Bastos Leandro Francisco; Coelho Marcio de Matos; Braga Fernao Castro^*

来源：Phytomedicine, 2010, 18(1): 80-86.

DOI：10.1016/j.phymed.2010.05.008

• Echinodorus grandiflorus
• Antiedematogenic effect
• Mice paw edema
• Flavonoids
• Diterpenes
• Hydroxycinnamoyltartaric acids

The leaves of Echinodorus grandiflorus (Alismataceae) are traditionally used in Brazil to treat inflammatory conditions. The aim of the present study was to evaluate the antidematogenic activity of crude aqueous, dichloromethane and hydroethanolic extracts from E. grandiflorus leaves using the carrageenan-induced paw edema model in mice, along with of fractions enriched in diterpenes, flavonoids and hydroxycin-namoyltartaric acids (HCTA). Significant inhibitions of paw edema were elicited by the 50% and 70% EtOH extracts (1000 mg/kg, p.o.), as well as by the fractions enriched in diterpenes (70-420 mg/kg, p.o.) and flavonoids (7.2-36 mg/kg, p.o.). Isovitexin, isoorientin, trans-aconitic and chicoric acids were identified in all extracts by HPLC analysis. Trans-aconitic acid itself exhibited significant antiedematogenic effect (270 mg/kg, p.o.). The biological activity correlated positively with the contents of flavonoids and diterpenes, but negatively with HCTA concentrations, demonstrating the participation of the two classes of compounds in the antiedematogenic activity of E. grandiflorus.

• 出版日期2010-12-15