Association of functional genetic variants in PPARδ encoding peroxisome proliferator-activated receptor delta with ischemic stroke in Chinese Uyghur population

作者：Tong, Yeqing; Zhan, Faxian; Cai, Li; Han, ShengHong; Guan, Xuhuan; Lin, Liangqiang; Li, Xiaoxia; Hou, Shuangyi; Lu, Qing^*; Liu, Jiafa

来源：Journal of the Neurological Sciences, 2015, 358(1-2): 82-86.

DOI：10.1016/j.jns.2015.08.025

• Ischemic stroke
• Functional polymorphisms
• Peroxisome proliferator-activated receptor Delta
• Case control study
• Odds ratio
• Uyghur population

PPAR delta belongs to a receptor family of ligand-activated transcription factors involved in the regulation of inflammation, cellular glucose uptake, protection against atherosclerosis and endothelial cell function. Through these effects, they might be involved with the ischemic stroke (IS). We recruited 200 subjects (100 IS patients diagnosed by CTs or/and magnetic resonance imaging (MRI) and 100 normal healthy controls from Chinese Uyghur population) to assess the nature of the functional polymorphisms of PPAR delta + 294T/C and any links with IS in this unique population. We found that the C allele of the PPAR delta + 294T/C polymorphism was more common in controls than IS subjects in the Uyghur population. C allele carriage may be associated with an increased risk of IS in Uyghurs with a strong trend (OR 1.79,95% Cl: 1.11-2.89). Additionally, the PPAR delta CC and TC genotypes were less frequent in Uyghur population than in Han population. Our population and ethnic-based study demonstrates that the PPAR delta + 294C allele maybe an independent risk of IS in Chinese Uyghurs especially in the male (OR 1.99, 95%CI:1.06-3.72) and obesity populations (OR 2.36, 95%CI: 1.19-4.67), which were consistent with Tunisian Population. Moreover, total cholesterol, fasting blood glucose, waist-to-hip ratio, hypertension, history of heart diseases, and negative events may increase the risk of IS, with a trend for HDL to be a protective factor for IS in the Uyghur population. However, larger populations are warranted to validate our findings.

• 出版日期2015-11-15
• 单位牡丹江医学院; 湖北省疾病预防控制中心; 华中科技大学; 武汉市疾病预防控制中心; 深圳市疾病预防控制中心