Melatonin down-regulates hTERT expression induced by either natural estrogens (17 beta-estradiol) or metalloestrogens (cadmium) in MCF-7 human breast cancer cells

作者：Martinez Campa Carlos M; Alonso Gonzalez Carolina; Mediavilla Maria D; Cos Samuel; Gonzalez Alicia; Sanchez Barcelo Emilio J^*

来源：Cancer Letters, 2008, 268(2): 272-277.

DOI：10.1016/j.canlet.2008.04.001

• hTERT
• estradiol
• cadmium
• melatonin
• MCF-7 cells

The goal was to evaluate whether melatonin (Mel) down-regulates hTERT expression induced by 17 beta-estradiol (E-2) or cadmium (Cd) in breast cancer cells. We found that: (a) Mel inhibits E-2 or Cd-induced hTERT transcription in hTERT-Luc transfected MCF-7 cells, (b) Mel significantly reduces E-2- and Cd-mediated hTERT transactivation triggered by ER alpha in transfected HeLa cells, (c) Mel inhibits hTERT expression induced by E-2 or Cd in MCF-7 cells. Melatonin inhibition of telomerase activity supports a possible role in treatment of estrogen-dependent tumors or carcinogenesis by environmental or occupational exposure to xenoestrogens.

• 出版日期2008-9-18