Acid Indigestion in the Endosome: Linking Signaling Dysregulation to Neurodevelopmental Disorders

作者：Yap Chan Choo; Winckler Bettina^*

来源：Neuron, 2013, 80(1): 4-6.

DOI：10.1016/j.neuron.2013.09.018

The sodium-proton exchanger NHE6 contributes to proper endosomal acidification. NHE6 mutations are also linked to autism-related disorders. In this issue of Neuron, using NHE6-knockout mice, Ouyang et al. (2013) uncover how dysregulation of endosomal pH leads to disturbances in BDNF signaling and neuronal morphogenesis defects.

• 出版日期2013-10-2