科研之友
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摘要
Background: IgA nephropathy has been reported as a renal involvement in Crohn%26apos;s disease. Crescentic IgA nephropathy, which accounts for fewer than 5% of cases of IgA nephropathy, has a poorer prognosis than other forms of crescentic glomerulonephritis. We recently experienced a case of rapidly progressive IgA nephropathy concurrent with exacerbation of Crohn%26apos;s disease. %26lt;br%26gt;Case presentation: An 18-year-old male diagnosed with Crohn%26apos;s disease underwent a hemicolectomy 2 years prior previously. He had maintained a state of Crohn%26apos;s disease remission with 5-aminosalicylic acid treatment. Four months prior to referral to the nephrology clinic, he experienced non-bloody diarrhea. He simultaneously developed proteinuria and microscopic hematuria with deterioration of renal function. Based on renal biopsy findings, the patient was diagnosed with crescentic IgA nephropathy. Immunostaining for interleukin-17 in renal tissue and previous exacerbated colonic ulcers was positive. Steroid pulse therapy was administered, followed by high-dose glucocorticoid and oral cyclophosphamide therapy. The patient%26apos;s renal function recovered and his gastrointestinal symptoms were alleviated. %26lt;br%26gt;Conclusions: We report a case of crescentic IgA nephropathy presenting with exacerbation of Crohn%26apos;s disease, and present a review of the literature focusing on the pathophysiologic relationship between these two conditions.
- 出版日期2012-8-6
