Size controlled fabrication of cellulose nanoparticles for drug delivery applications

作者：Chin Suk Fun^*; Jimmy Fiona Beragai; Pang Suh Cem

来源：JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2018, 43: 262-266.

DOI：10.1016/j.jddst.2017.10.021

• Cellulose
• Nanoparticles
• Drug carriers
• Size controlled
• Nanoprecipitation

Spherically shaped cellulose nanoparticles with average particle diameter range between 70 and 365 nm were fabricated from cotton fibers by a simple nanoprecipitation method. The average particle diameter of cellulose nanoparticles could be precisely controlled by modulating the synthesis conditions such as cellulose solution concentration and volume ratio of solvent/non-solvent. Methylene blue (MB) as a model hydrophilic drug was loaded onto cellulose nanoparticles via the in-situ nanoprecipitation process. The loading efficiency and release profile of MB were observed to be affected by the average particle diameter of cellulose nanoparticles.

• 出版日期2018-2