A Biodegradable Polymersome Containing Bcl-xL siRNA and Doxorubicin as a Dual Delivery Vehicle for a Synergistic Anticancer Effect

作者：Kim Hyun Ouk; Kim Eunjung; An Yonghee; Choi Jihye; Jang Eunji; Choi Eun Bi; Kukreja Aastha; Kim Myeong Hoon; Kang Byunghoon; Kim Dong Joo; Suh Jin Suck; Huh Yong Min^*; Haam Seungjoo

来源：Macromolecular Bioscience, 2013, 13(6): 745-754.

DOI：10.1002/mabi.201200448

• bcl-xL-specific siRNA
• biodegradable
• doxorubicin
• drug delivery systems
• polymersomes

Combined cancer treatment via co-delivery of siRNAs and an anticancer drug can be a promising strategy due to the synergistic effect of simultaneously minimizing gene/drug administration. In this study, Bcl-xL siRNA and doxorubicin (DOX) are encapsulated into designed methoxy-poly(ethylene glycol)-block-poly(D,L-lactic acid) (mPEG-b-PLA) block copolymer polymersomes (PSomes). A study of the cytotoxicity of Bcl-xL siRNA and DOX co-encapsulated PSomes (CPSomes) shows more inhibited proliferation of MKN-45 and MKN-28 human gastric cancer cell lines than only gene- and drug-loaded ones. Consequently, these results demonstrate that co-delivery of genes and drugs using PSomes results in a synergistic efficacy and indicates the potential of PSomes as efficient nanocarriers for combined cancer therapy.

• 出版日期2013-6