Association study of TRAF1/C5 polymorphism (rs10818488) with susceptibility to rheumatoid arthritis and systemic lupus erythematosus: A meta-analysis

作者：Xu Ke; Peng Hui; Zhou Mo; Wang Wei; Li Rui; Zhu Kao Kao; Zhang Min; Wen Peng Fei; Pan Hai Feng; Ye Dong Qing^*

来源：Gene, 2013, 517(1): 46-54.

DOI：10.1016/j.gene.2012.12.092

• Tumor necrosis factor-receptor associated factor 1
• Polymorphism
• Rheumatoid arthritis
• Systemic lupus erythematosus
• Meta-analysis

To determine whether the tumor necrosis factor (TNF)-receptor associated factor 1/complement component 5 (TRAF1/C5) polymorphism (rs10818488) confers susceptibility to rheumatoid arthritis (RA) and systemic lupus erythematous (SLE), a meta-analysis was performed. A total of 11 studies with 17 comparisons (11 for RA, 6 for SLE) were available for this meta-analysis, which consisted of 13,456 patients, 12,259 controls for RA and 1,894 patients, 6,729 controls for SLE. A significant association of the A allele of TRAF1/C5 polymorphism (rs10818488) with RA susceptibility was detected in the North Africa population (OR = 1557, 95% Cl: 1.225-1.977). Furthermore, the association between this allelic variant and SLE risk was additionally found in population of European (OR = 1.247, 95% Cl: 1.060-1.466). Analysis also showed the A/G allelic frequency of TRAF1/C5 variant (rs10818488), in different healthy populations, had a different distribution (chi(2) = 269.41, P<0.001). Taken together, our study demonstrates that the TRAF1/C5 polymorphism (rs10818488) may confer susceptibility to RA in North Africa population, and in European population, it might be a contributory factor towards SLE.

• 出版日期2013-3-15
• 单位安徽医科大学