Agreement among three types of spectral-domain optical coherent tomography instruments in measuring parapapillary retinal nerve fibre layer thickness

作者：Kanamori Akiyasu^*; Nakamura Makoto; Tomioka Mari; Kawaka Yuki; Yamada Yuko; Negi Akira

来源：British Journal of Ophthalmology, 2012, 96(6): 832-837.

DOI：10.1136/bjophthalmol-2011-301084

Backgrounds/aims To evaluate the agreement of parapapillary retinal nerve fibre layer (RNFL) thickness among three spectral-domain optical coherence tomography (OCT) instruments. %26lt;br%26gt;Methods Two hundred and three glaucomatous eyes and 88 normal eyes were imaged by Cirrus, RTVue and 3D OCT. The average and the four quadrant RNFL thicknesses were evaluated. Agreement among RNFL measurements was evaluated using Bland-Altman analysis and linear regression analysis. The percentage of each quadrant in the average RNFL thickness value was compared among the three instruments. %26lt;br%26gt;Results Cirrus showed significantly smaller thickness values than RTVue (difference=8.8 mu m, p%26lt;0.0001) and 3D OCT (difference=8.1 mu m, p%26lt;0.0001). Although RNFL measurements among the instruments were highly correlated, the Bland-Altman analysis revealed proportional biases for most of the pair-wise agreements. Additionally, 3D OCT showed strong proportional biases with RTVue and 3D OCT. RTVue had a smaller occupied proportion of nasal quadrants (30.2%) and a larger proportion of inferior quadrants (32.4%) compared with Cirrus and 3D OCT. %26lt;br%26gt;Conclusions RNFL measurements among the instruments were well correlated but had different values for thickness. The measurement circle of RTVue might be more superior-temporally located compared with the other instruments. Differences in the measurement protocols might be affected by the disagreements. These instruments should not be used interchangeably.

• 出版日期2012-6