New Class of Pyrimidinesulfamoyl Containing Pyrazole and Pyrrole Derivatives and Their Antioxidant Activity

作者：Maddila Suresh; Jonnalagadda Sreekanth B^*

来源：Letters in Organic Chemistry, 2013, 10(5): 374-379.

DOI：10.2174/1570178611310050013

• Antioxidant activity
• synthesis
• pyrimidin-2-yl-sulfamoyl-cinnamamide
• pyrrole-3-carboxamides
• pyrazole-3-carboxamides

A new series of pyrimidinesulfamoyl-1H-pyrrole-3-carboxamides (3a-e) and pyrimidinesulfamoyl-1H-pyrazole-3-carboxamides (4a-e) moiety was prepared using intermediate compounds pyrimidinesulfamoyl cinnamamides (2a-e). On the basis of the FT-IR, H-1 NMR, C-13 NMR, LCMS spectral results and elemental analysis data, the structures of newly synthesized compounds were confirmed. Based on results of their in-vitro antioxidant activities, compounds such as 3b, 3c and 3d exhibited promising antioxidant activities and while remaining compounds such as 4c, 4b, 3a, 4d, 4a, 3e, 4e and 2c showed moderate to good antioxidant activity.

• 出版日期2013-6