Next-Generation Medicine: Combining BCR-ABL and Hedgehog-Targeted Therapies

作者:Dao Kim Hien T; Tyner Jeffrey W*
来源:Clinical Cancer Research, 2013, 19(6): 1309-1311.
DOI:10.1158/1078-0432.CCR-12-3934

摘要

Disease relapse remains a major cause of death in patients with BCR-ABL-positive leukemia despite advances in treatment with kinase inhibitors. Significant efforts are underway to target pathways that maintain leukemia stem cells. Targeting these pathways holds promise for definitive leukemia eradication or improvement of the effectiveness of currently available therapies. Clin Cancer Res; 19(6); 1309-11.

  • 出版日期2013-3-15