Low Catalyst Loadings for Ligand-Free Copper(I)-Oxide-Catalyzed N-Arylation of Methanesulfonamide in Water

作者：Tan Bryan Yong Hao; Teo Yong Chua^*; Seow Ai Hua

来源：European Journal of Organic Chemistry, 2014, 2014(7): 1541-1546.

DOI：10.1002/ejoc.201301561

• N-Arylation
• Cross-coupling
• Copper
• Ligand-free reactions
• Sulfonamides

A simple and practical protocol for the cross-coupling of methanesulfonamide and aryl iodides under ligand-free copper(I)-oxide-catalyzed conditions in water is reported. The method allows the preparation of a wide variety of synthetically useful N-arylated methanesulfonamides in good to excellent yields (up to 90%) under the optimized conditions.

• 出版日期2014-3
• 单位南阳理工学院