A novel three-step synthesis of Celecoxib via palladium-catalyzed direct arylation

作者：Gaulier Steven M^*; McKay Reuben; Swain Nigel A

来源：Tetrahedron Letters, 2011, 52(45): 6000-6002.

DOI：10.1016/j.tetlet.2011.08.174

• Direct arylation
• Celecoxib
• Pd catalysis

A novel three linear step synthesis of Celecoxib was achieved in 33% overall yield via a key regioselective direct C-H arylation reaction between a 1,3-disubstituted pyrazole and an aryl bromide.

• 出版日期2011-11-9