Stem Cells for Neonatal Brain Disorders

作者：Ahn So Yoon; Chang Yun Sil; Park Won Soon^*

来源：Neonatology, 2016, 109(4): 377-383.

DOI：10.1159/000111905

• Mesenchymal stem cells
• Cell transplantation
• Infant newborn
• Intraventricular hemorrhage
• Hypoxic-ischemic encephalopathy
• Neonatal stroke

Despite recent advances in neonatal intensive care medicine, neonatal brain injury resulting from intraventricular hemorrhage or hypoxic-ischemic encephalopathy remains a major cause of neonatal mortality and neurologic morbidities in survivors. Several studies have indicated that stem cell therapy is a promising novel therapy for neonatal brain injury resulting from these disorders. This review summarizes recent advances in stem cell research for treating neonatal brain injury due to intraventricular hemorrhage or hypoxicischemic encephalopathy with a particular focus on preclinical data, covering important issues for clinical translation such as optimal cell type, route, dose and timing of stem cell therapy, and translation of these preclinical results into a clinical trial.

• 出版日期2016