Application toward Drug Delivery System Using beta-1,3-Glucan

作者：Maegawa Yoshiya^*; Mochizuki Shinichi; Miyamoto Noriko; Sanada Yusuke; Sakurai Kazuo

来源：Trends in Glycoscience and Glycotechnology, 2015, 27(153): 13-29.

DOI：10.4052/tigg.1407.1

• beta-1,3-D-glucan
• DDS
• CpG-ODN
• AS-ODN
• SAXS

A beta-1,3-D-glucan called Schizophyllan (SPG) can form a novel complex with homo oligodeoxynucleotides (ODNs) via the combination of hydrogen bonding and hydrophobic interactions. Dectin-1 is a major receptor involved in the recognition of beta-1,3-D-glucans and expressed on antigen presenting cells (APCs) including macrophages, dendritic cells, monocytes, neutrophils, and a subset of T cells. Therefore, the SPG/ODN complex can be used as APCs cell-specific delivery of antisense ODNs (ASODNs) or unmethylated CpG sequences (CpG-ODNs). In fact, AS-ODN/SPG complex protected mice from LPS-induced hepatitis and CpG-ODN/SPG complex induced high antibody titers when it was administered to cynomolgus monkeys as adjutant of influenza vaccine. These results indicate that SPG can be an excellent drug delivery system carrier targeting APCs.

• 出版日期2015-1