Bortezomib/dexamethasone followed by autologous stem cell transplantation as front line treatment for light-chain deposition disease

作者：Tovar Natalia; Teresa Cibeira Ma; Rosinol Laura; Sole Manel; Fernandez de larrea Carlos; Escoda Lourdes; Rovira Montserrat; Blade Joan^*

来源：European Journal of Haematology, 2012, 89(4): 340-344.

DOI：10.1111/j.1600-0609.2012.01821.x

• light-chain deposition disease
• bortezomib
• autologous stem cell transplantation
• kidney transplant

Limited data has been published on the treatment results in patients with light-chain deposition disease (LCDD). Whenever possible, high-dose melphalan followed by autologous stem cell transplantation (ASCT) has been the first treatment option, achieving somehow better results than conventional therapy. However, and based on the promising results obtained by treating patients with light-chain amyloidosis with bortezomib/dexamethasone, new treatment options appear in LCDD. Herein, we describe three patients with LCDD treated with bortezomib/dexamethasone followed by high-dose melphalan and autologous transplantation. We believe that this new approach should be the treatment of choice in this disease. In addition, those patients achieving hematologic complete response after ASCT could benefit from a kidney transplant if the renal impairment requiring dialysis persists.

• 出版日期2012-10