A facile approach to manipulation of osteogenic activity of orthopedic implants by in situ electrically controlled wettability

作者：Chen, Dayong; Gao, Meng; Fu, Yunfeng^*; Xu, Xiangyang; Hao, Zhao

来源：Electrochimica Acta, 2015, 182: 841-846.

DOI：10.1016/j.electacta.2015.09.156

• implants
• osteointegration
• poly(3,4-ethylenedioxythiophene)
• biomacromolecules
• electrical control

In this paper, a facile approach to manipulating osteogenic activity of orthopedic implants by in situ electrically controlled wettability was developed. Glycosaminoglycans (GAGs), the major organic extracellular matrix (ECM) components, were electrochemically doped in nanostructured poly(3,4-ethylenedioxythiophene) (NPEDOT) on Ti-6Al-4 V orthopedic implants. The controlled wettability of NPEDOT/GAGs was achieved by in situ applying electrical stimulus. Moreover, the in situ electrically controlled wettability could be utilized to implement the manipulation of osteogenic activity of orthopedic implants. This facile strategy may open up a new avenue to electrically responsive biomedical applications.

• 出版日期2015-11-10
• 单位中南大学