Hyaluronidase Inhibitors from "Cimicifugae Rhizoma" (a Mixture of the Rhizomes of Cimicifuga dahurica and C. heracleifolia)

作者:Iwanaga Atsufumi; Kusano Genjiro; Warashina Tsutomu; Miyase Toshio*
来源:Journal of Natural Products, 2010, 73(4): 573-578.
DOI:10.1021/np900675n

摘要

From the 80% acetone extract of "Cimicifugae Rhizoma" (a mixture of Cimicifuga dahurica and C. heracleifolia used medicinally), seven new fukiic acid derivatives (1-7) and a new phenylethanoid derivative (8) were isolated along with eight known compounds (9-16). Fukinolic acid (9) and cimicifugic acids A-J (10-16, 5-7) showed stronger hyaluronidase inhibitory activities than the positive control, rosmarinic acid.

  • 出版日期2010-4