Multifunctional Monoamine Oxidases and Cholinesterases Inhibitory Effects, as well as UPLC-DAD-MS Chemical Profile of Alkaloid Fractions Obtained from Species of the Palicoureeae Tribe

作者：Klein Junior Luiz Carlos; Passos Carolina dos Santos; Salton Juliana; de Bitencourt Fernanda Gobbi; Funez Luis; de Andrade Jean Paulo; Villalobos Jonathan Parra; de Loreto Bordignon Sergio Augusto; Gasper Andre Luis; Vander Heyden Yvan; Henrique Amelia Teresinha

来源：Natural Product Communications, 2016, 11(9): 1271-1274.

DOI：10.1177/1934578x1601100920

• Psychotria
• Palicourea
• Rudgea
• Indole alkaloids
• Cholinesterases
• Monoamine oxidases

In the present study, the effects were evaluated of alkaloid fractions (AFs) from Psychotria species and correlated genera, Palicourea and Rudgea, on monoamine oxidases (MA05) and cholinesterases (ChEs). By HPLC-DAD and UPLC-DAD-MS analyses, indole alkaloids (IA) were detected in all AFs. For the Psychotria and Palicourea species, these IA corresponded to tetrahydro-beta-carboline alkaloids (TH beta CA). On the other hand, pyrrolidinoindoline core compounds were observed for Rudgea species. Regarding their pharmacological activities, none of the AFs was able to inhibit AChE. However, the BChE activity was impaired by the Psychotria and Palicourea AFs. In addition, MAO-A was inhibited by both AFs, but only Psychotria nemorosa AF was able to inhibit significantly MAO-B. Rudgea AFs demonstrated a poor inhibitory profile on MAO-A. Taken together, our results highlighted the Psychotria and Palicourea genera as important sources of scaffolds for the development of MAO-A and BChE inhibitors aiming at the treatment of neurodegenerative and neuropsychiatric diseases.

• 出版日期2016-9