Aryl carboxylic acid reduction and further reactions with GABA and glucose promoted by whole cells of Xylaria arbuscula

作者：Amaral Luciana da Silva^*; Rodrigues Filho Edson

来源：Journal of Molecular Catalysis B: Enzymatic , 2015, 113: 90-94.

DOI：10.1016/j.molcatb.2015.01.001

• Xylaria arbuscula
• Aromatic carboxylic acid reduction
• GABA
• Amino acid conjugation
• Glycosylation

Xylaria arbuscula was collected from a "Cypress" tree, Cupressus lusitanica. The whole cells of this endophytic fungus were used in screening for microbial bioreduction of aryl acids. Different p-substituted benzoic acids were evaluated. However, only p-bromobenzoic acid, p-chlorobenzoic acid and p-nitrobenzoic acid were converted to their corresponding alcohols. Aryl acid metabolism of X. arbuscula included GABA incorporation and glycosylation when the substrates were p-bromobenzoic and p-chlorobenzoic acids were also observed. The substrates p-hydroxybenzoic and p-aminobenzoic acids were not transformed. These results could suggest that electron-withdrawing groups at para orientation activate the substrate for reduction.

• 出版日期2015-3