Access to trans-3,4-Dihydroxy-2-alkylpyrrolidines and Piperidines by Use of Stereodefined Cyclic N,O-Acetals as a Diversity-Generating Element

作者：Kang Soyeong; Kim Dong gil; Rhee Young Ho^*

来源：Chemistry - A European Journal, 2014, 20(49): 16391-16396.

DOI：10.1002/chem.201404659

• diastereoselectivity
• enantioselectivity
• heterocycles
• natural products
• synthetic methods

A highly efficient and stereoselective synthetic pathway towards trans-3,4-dihydroxy-2-alkylpyrrolidines and piperidines is described. The nature of the protecting groups on the hydroxyl moieties played a crucial role on the trans selectivity. By using this method, a concise total synthesis of (-)-2-epilentiginosine has been achieved.

• 出版日期2014-12-1