Alginate-Based Biodegradable Superabsorbents as Candidates for Diclofenac Sodium Delivery Systems

作者：Pourjavadi A^*; Zeidabadi F; Barzegar Sh

来源：Journal of Applied Polymer Science, 2010, 118(4): 2015-2023.

DOI：10.1002/app.32205

• control release
• diclofenac sodium
• polysaccharide
• drug delivery system
• hydrogels

Novel types of highly swelling hydrogels were prepared by grafting crosslinked polyacrylamide-co-poly-2-acrylamido-2-methylpropane sulfonic acid (PAAm-co-PAMPS) chains onto sodium alginate (Na-Alg) through a free radical polymerization method. The superabsorbent formation was confirmed by Fourier transform infrared spectroscopic (FM). The controlled release behavior of diclofenac sodium (DS) from superabsorbent polymer was fact investigated, and shown that the release profiles of DS from superabsorbent polymer were slow in simulated gastric fluid (SGF, pH 1.2) over 3 h, but nearly all of the injtial drug content was released in simulated intestinal fluid (SIF, pH 7.4) within 21 h after changing media. Overall the results demonstrated that biodegradable superabsorbent could successfully deliver a drug to the intestine without losing the drug in the stomach, and could be potential candidates as an orally administrated drug delivery system.

• 出版日期2010-11-15