A study of the association of glutathione S-transferase M1/T1 polymorphisms with susceptibility to vitiligo in Egyptian patients

作者：Aly Dalia Gamal^*; Salem Samar Abdallah; Amr Khalda Sayed; Abd El Hamid Mahmoud Fawzy

来源：Anais Brasileiros de Dermatologia, 2018, 93(1): 54-58.

DOI：10.1590/abd1806-4841.20185796

• Glutathione S-Transferase pi
• Oxidative stress
• Polymorphism, single nucleotide
• Vitiligo

BACKGROUND: The association of glutathione S-transferases M1/T1 (GSTM1/T1) null polymorphisms with vitiligo was proposed in several studies including two Egyptian studies with contradictory results.
OBJECTIVE: The aim here was to assess the association between GSTM1/T1 null polymorphisms and the susceptibility to vitiligo in a larger sample of Egyptian patients with generalized vitiligo.
METHODS: This study included 122 vitiligo patients and 200 healthy controls that were age, and gender matched. Assessment of GSTM1/T1 gene polymorphisms was done using a multiplex polymerase chain reaction (PCR).
RESULTS: Increased odds of generalized vitiligo was observed with the null genotypes of GSTM1 and GSTT1 polymorphisms (P<0.05). Controls with GSTM1 null/GSTT1+ heterozygosis presented with a 2.97 odds protection from having generalized vitiligo (OR=2.97, 95% CI=1.1-7.7) (P=0.02) compared with patients.
STUDY LIMITATIONS: Small sample size of patients.
CONCLUSIONS: This study showed a significant trend towards an association with the combination of the GSTM1/GSTT1 double null polymorphism and generalized vitiligo. Individuals with GSTM1 null/GSTT1+ heterozygosis have a 2.97 odds protection from having generalized vitiligo compared with patients. It was is the first time, to our knowledge, that such an association has been reported.

• 出版日期2018-2