Mineral metabolism management in Canadian peritoneal dialysis patients

作者：Soroka S D^*; Beard K M; Mendelssohn D C; Cournoyer S H; Da Roza G A; Geary D F

来源：Clinical Nephrology, 2011, 75(5): 410-415.

DOI：10.5414/CNP75410

• calcium-based phosphate binders
• mineral metabolism
• peritoneal dialysis
• sevelamer

Background: Abnormal mineral metabolism is associated with increased morbidity and mortality in dialysis patients. Therefore, the goal of this study was to compare a) mineral metabolism control among a cohort of Canadian peritoneal dialysis (PD) patients to K/DOQI-defined targets and b) the effect of different treatment strategies on mineral metabolism parameters. Methods: We looked at a cohort of 317 Canadian PD patients from 9 clinics that used the PhotoGraph (TM) software program which tracks mineral metabolism management. Serum phosphorus (P), calcium (Ca) and intact parathyroid hormone (iPTH) values were collected for the patients. Data were categorized and analyzed by the type of phosphate binder prescribed, vitamin D use, and dosing and reimbursement criteria for the phosphate binder, sevelamer. Results: The majority of patients achieved K/DOQI-set targets for serum P. Patients who resided in Quebec (QC), which had greater access to sevelamer, had lower mean concentrations of P and Ca, were less likely to take Ca-based phosphate binders (CBBs) exclusively and were exposed to less exogenous Ca than in Ontario (ON). Conclusion: Availability of the phosphate binder sevelamer and reduced doses of elemental Ca were associated with more mineral metabolism parameters within suggested target ranges. Further studies that focus on patient outcomes are warranted.

• 出版日期2011-5