Application of Thiol-Ene Photopolymerization for Injectable Intraocular Lenses: A Preliminary Study

作者：Niu Guoguang; Song Li; Zhang Hongbin; Cui Xiaopeng; Kashima Miki; Yang Zhou; Cao Hui; Wang Guojie; Zheng Yudong; Zhu Siquan; Yang Huai^*

来源：Polymer Engineering and Science, 2010, 50(1): 174-182.

DOI：10.1002/pen.21465

The thiol-ene photopolymerization, which could be achieved with less ultraviolet (UV) intensity and photoinitiator content was first introduced into the application of injectable intraocular lenses (IOLs), thus the damages to the eye from the UV radiation and photoinitiator toxicity were greatly reduced. The bulk samples were obtained from the mixture of poly(ethylene glycol) diacrylate (PEGDA) and pentaerythritol tetrakis(3-mercaptopropionate) (PTMP) by the thiol-ene photopolymerization. It was found that PEGDA-PTMP bulk samples had the similar transparency and the hydrophilicity as the ones from PEGDA by homophotopolymerization. Meanwhile, when PTMP was added into PEGDA, the elastic modulus of the bulk samples was decreased and their flexibility was improved. The experimental results indicated that the thiol-ene photopolymerization was one potential method to obtain the ideal injectable IOLs, although many works have to be done in the future study, such as selecting proper monomers and testing the biocompatibility of polymerized samples. POLYM. ENG. SCL, 50:174-182, 2010.

• 出版日期2010-1
• 单位中国科学技术大学; 首都医科大学