A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism

作者：Lawrence Matthew J; Sabra Ahmed; Mills Gavin; Pillai Suresh G; Abdullah Wendy; Hawkins Karl; Morris Roger H K; Davidson Simon J; D'Silva Lindsay A; Curtis Daniel J; Brown Martin R; Weisel John W; Williams Phylip R; Evans Phillip A^*

来源：British Journal of Haematology, 2015, 168(4): 571-575.

DOI：10.1111/bjh.13173

• blood coagulation
• warfarin
• venous thrombosis
• haemostasis
• anticoagulation

This study compared patients with venous thromboembolism (VTE) to non-VTE patients using a biomarker of clot microstructure (d(f)) and clot formation time (T-GP). d(f) was the only marker that identified a significant difference (P<0001) between the VTE (n=60) and non-VTE cohorts (n=69). The abnormal' clot microstructures in the VTE patients suggests either inadequate response to anticoagulant therapy or the presence of a procoagulant state not detected by other markers of coagulation (i.e., International Normalized Ratio). Furthermore, elevated values of d(f) in first time VTE patients who later develop a secondary event indicates that d(f) may identify those at risk of recurrence.

• 出版日期2015-2