A fluorescent, paramagnetic and PEGylated gold/silica nanoparticle for MRI, CT and fluorescence imaging

作者：van Schooneveld Matti M; Cormode David P; Koole Rolf; van Wijngaarden J Timon; Calcagno Claudia; Skajaa Torjus; Hilhorst Jan; 't Hart Dannis C; Fayad Zahi A; Mulder Willem J M^*; Meijerink Andries

来源：Contrast Media and Molecular Imaging, 2010, 5(4): 231-236.

DOI：10.1002/cmmi.376

• molecular imaging, cellular uptake, MRI
• CT, contrast agents
• paramagnetic agents, fluorescent probes, trimodal probes, nanoparticles

An important challenge in medical diagnostics is to design all-in-one contrast agents that can be detected with multiple techniques such as magnetic resonance imaging (MRI), X-ray computed tomography (CT), positron emission tomography (PET), single photon emission tomography (SPECT) or fluorescence imaging (FI). Although many dual labeled agents have been proposed, mainly for combined MRI/FI, constructs for three imaging modalities are scarce. Here gold/silica nanoparticles with a poly(ethylene glycol), paramagnetic and fluorescent lipid coating were synthesized, characterized and applied as trimodal contrast agents to allow for nanoparticle-enhanced imaging of macrophage cells in vitro via MRI, CT and FI, and mice livers in vivo via MRI and CT. This agent can be a useful tool in a multitude of applications, including cell tracking and target-specific molecular imaging, and is a step in the direction of truly multi-modal imaging.

• 出版日期2010-8