A mathematical model for predicting putative association between E2/T ratio and the development of benign prostate hyperplasia in rats

作者：Liu, Xiang-Yun^*; Liu, Xin; Xu, Li; Gui, Bo; Yang, Qin-Yu; Yan, Jian-Yan; Sun, Zu-Yue^*

来源：Biology of Reproduction, 2019, 100(1): 133-138.

DOI：10.1093/biolre/ioy170

• estradiol
• testosterone ratio
• benign prostate hyperplasia
• mathematical modeling
• prostate tissue
• rat

Benign prostatic hyperplasia (BPH) develops more likely with increasing age and changing serum concentrations of circulating estradiol (E-2) and/or testosterone (T). In this study, we explored the relationship between serum E-2/T ratio and BPH risk in rats by fitting a mathematical model. A total of 176 rats were randomized to one of the following treatment groups: normal control, castrated control, and 20 more groups of castrated animals treated with increasing dose combinations of T and E-2, once daily for 30 days. Serial blood samples were obtained to determine serum T and E-2 levels by magnetic bead enzyme-linked immunosorbent assay. Prostate tissue was taken to measure prostate volume. MATLAB software was used to simulate the relationship between prostate/body weight ratio (PBR) and E-2/T ratio with a mathematical equation. The values of PBR, E-2 and T in the treatment groups were significantly higher than those in the control groups. Stepwise regression showed that PBR was a function of E-2 and T. PBR=-0.1782+0.0081 E-2+0.063 T - 0.6x10(-5) E-2(2) - 0.28x10(-3) T-2. E-2/T ratio change may be one of the risk factors for PBR, which is associated with the development of BPH.
E-2 /T ratio change may be one of the risk factors for PBR, which is associated with the development of BPH.

• 出版日期2019-1
• 单位上海体育学院; 东华大学; 上海市计划生育科学研究所