科研之友
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摘要
Chloro-substituted phenothiazines and phenoxazines were successfully derivatized with phenylboronic and styrylboronic acids using Suzuki-Miyaura cross-coupling reaction catalyzed by Pd(0)/XPhos for the first time in good yields. The protocol employed 4mol% Pd and 7mol% XPhos with K3PO4 in acetonitrile at 80 degrees C. The reaction condition is compatible with carbonyl and unprotected N-H groups in substrates. Structural assignments were established by combined spectroscopic (UV, IR, H-1, and C-13 NMR), MS, and elemental analytical data.
- 出版日期2016-11
