Vitamin E-modulated gene expression associated with ROS generation

作者：Nakamura Yukiko K; Omaye Stanley T^*

来源：Journal of Functional Foods, 2009, 1(3): 241-252.

DOI：10.1016/j.jff.2009.02.002

• Vitamin E
• Tocopherol
• Antioxidants
• Reactive oxygen species

Although the beneficial effects of vitamin E on reactive oxygen species (ROS)-related diseases, such as cardiovascular disease (CVD), have been suggested by epidemiological and animal studies, clinical trials have failed to confirm the efficacy of vitamin E. Vitamin E has a defined role as an antioxidant. Recent studies indicate non-antioxidant roles of vitamin E serving as a regulator of gene/protein expression and enzyme inhibitor. Vitamin E may control ROS generation possibly in both antioxidant-dependent and independent manners, since vitamin E has shown inhibitory effects on activities and expression of ROS generating enzymes. However, the effects of vitamin E appear to depend on microenvironment, such as its concentration and the presence of oxidants/antioxidants. The objective of this article is to review the roles of vitamin E, in particular vitamin E-modulated gene expression, for better understanding the molecular mechanisms of vitamin E and for preventive and therapeutic strategies of ROS-related diseases.

• 出版日期2009-7