Deracemization and the first CD spectrum of a 3(10)-helical peptide made of achiral alpha-amino-isobutyric acid residues in a chiral membrane mimetic environment

作者：Ceccacci Francesca; Mancini Giovanna^*; Rossi Paola; Scrimin Paolo; Sorrenti Alessandro; Tecilla Paolo

来源：Chemical Communications, 2013, 49(86): 10133-10135.

DOI：10.1039/c3cc44713h

Interaction of the racemic helical homo-octapeptide made by the achiral C-alpha-methyl alanine (Aib) amino acid with a chiral enantiopure micellar aggregate made of N-dodecylproline led to the deracemization of the helical Aib sequence thus allowing us to obtain for the first time the CD signature in water of a 3(10) helix devoid of the contribution of any chiral amino acid.

• 出版日期2013