Autophagy and its possible roles in nervous system diseases, damage and repair

作者：Rubinszfein David C^*; DiFiglia Marion; Heintz Nathaniel; Nixon Ralph A; Qin Zheng Hong; Ravikumar Brinda; Stefanis Leonidas; Tolkovsy Aviva

来源：Autophagy, 2005, 1(1): 11-22.

DOI：10.4161/auto.1.1.1513

• autophagy
• Alzheimer's disease
• Parkinson's disease
• Huntington's disease
• prion
• alpha-synuclein
• amyloid
• apoptosis

Increased numbers of autophagosomes/autophagic vacuoles are seen in a variety of physiological and pathological states in the nervous system. In many cases, it is unclear if this phenomenon is the result of increased autophagic activity or decreased autophagosome-lysosome fusion. The functional significance of autophagy and its relationship to cell death in the nervous system is also poorly understood. In this review, we have considered these issues in the context of acute neuronal injury and a range of chronic neurodegenerative conditions, including the Lurcher mouse, Alzheimer's, Parkinson's, Huntington's and prion diseases. While many issues remain unresolved, these conditions raise the possibility that autophagy can have either deleterious or protective effects depending on the specific situation and stage in the pathological process.

• 出版日期2005-6
• 单位河北医科大学