科研之友
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摘要
Objective With the vast development of theranostics and, recently, Ga-68-radiolabeled molecules, there is also a need for novel, smaller, flexible, safe, and efficient modular automated synthesis systems in different clinical settings. The aim of our study was to determine the shielding properties of the modular self-shielded automated radiosynthesis box and determine its suitability for routine preparation of different radiopharmaceuticals to be used for diagnosis and therapy. Methods To evaluate shielding properties, shielding factors were determined using two different radiation sources: Cs-137 and Ga-68. The dose rates were measured at critical points at the surface and 1 m distance from the surface. Three different methods were used to concentrate and purify Ga-68 generator eluate. Performance of the system was tested by evaluating several radiolabeling applications using Ga-68, Lu-177, and Y-90. Results Dose rates measured at the surface did not exceed 9 mu Sv/h for Ga-68 and 20 mu Sv/h when using Cs-137. On average, dose rates at the surface were reduced for factors of 1665 and 906, respectively. Different DOTA peptides were labeled successfully with Ga-68 with radiochemical purities more than 94% using three different radiolabeling methods. Lu-177-DOTATATE and Y-90-DOTATATE were synthesized reproducibly with a radiochemical purity of more than 99% and more than 97%, respectively. Conclusion A self-shielded radiosynthesis box is a unique solution for nuclear medicine departments that lack space for installation of standard automated synthesis systems set in large and heavy dedicated PET synthesis boxes. Shielding properties are sufficient for safe clinical use for both PET and beta(-) radioisotopes. Because of its modular design and the simple adaptability of system parameters, the system can be used for the preparation of different clinically used radiopharmaceuticals and is also useful for research purposes.
- 出版日期2016-2
