Anti-Inflammatory Effect of Black Raspberry Seed Oil in High-Fat Diet-Induced Obese Mice

作者：Lee Hee Jae; Jung Hana; Cho Hyunnho; Hwang Keum Taek^*

来源：Journal of Food Biochemistry, 2015, 39(5): 612-621.

DOI：10.1111/jfbc.12169

The purpose of the study was to determine the anti-inflammatory effect of black raspberry seed (BRS) oil on high-fat diet (HFD)-induced obese mice. BRS oil was composed of 57.0% linoleic and 29.4% -linolenic acids. Five-week-old C57BL/6 mice were fed HFD: BRS oil diet consisting of 50% calories from lard and 10% from BRS oil, while control diet consisted of 50% calories from lard, 5% from soybean oil and 5% from corn oil. Inflammation-involved proteins were lower in the liver of the mice fed the BRS oil than those in the control. mRNA levels of pro-inflammatory markers in the liver and adipose tissue of the BRS oil group were lower and anti-inflammatory markers were higher in the BRS oil group compared with the control. The results of this study suggest that BRS oil may be a good source of -linolenic acid, an n-3 fatty acid, with anti-inflammatory effects on HFD-induced obese mice.
Practical ApplicationsBlack raspberry seed (BRS) oil, which could be obtained from black raspberry wine pomace, contains about 30% -linolenic acid, an n-3 fatty acid. Supplementation of BRS oil might lower inflammation in high-fat diet-induced obese mice, when measuring protein and mRNA levels of pro- and anti-inflammatory markers in the liver and adipose tissue of the mice. The results would promote utilization of BRS, a by-product of wine production, and consequently help black raspberry producers and manufacturers.

• 出版日期2015-10