Urine 3-hydroxykynurenine is higher during the postovulatory phase than in the preovulatory phase indicating a higher vitamin B-6 requirement

作者：Shibata Katsumi^*

来源：Bioscience Biotechnology and Biochemistry, 2014, 78(10): 1757-1760.

DOI：10.1080/09168451.2014.925779

• ovulatory phase
• vitamin B-6
• menstrual cycle
• nicotinamide
• tryptophan

The relationship between l-tryptophan to nicotinamide metabolism and the menstrual cycle of Japanese women was investigated. Nine metabolism intermediates from urine samples collected during the preovulatory and postovulatory phases were measured. Only urine 3-hydroxykynurenine was higher in the postovulatory phase than in the preovulatory phase. This increase in 3-hydroxykynurenine suggests a decreased reaction of 3-hydroxykynurenine -> 3-hydroxyanthranilic acid catalyzed by kynureninase, a vitamin B-6 enzyme.

• 出版日期2014-10-3