alpha %26apos;(H) -Dicalcium silicate bone cement doped with tricalcium phosphate: characterization, bioactivity and biocompatibility

作者：de Aza Piedad N^*; Zuleta Fausto; Velasquez Pablo; Vicente Salar Nestor; Reig Juan A

来源：Journal of Materials Science: Materials in Medicine , 2014, 25(2): 445-452.

DOI：10.1007/s10856-013-5084-1

The influence of phosphorus doping on the properties of -dicalcium silicate (C2S) bone cement was analyzed, in addition to bioactivity and biocompatibility. All the cements were composed of a solid solution of TCP in C2S (-C2Sss) as the only phase present. The compressive strength ranged from 3.8-16.3 MPa. Final setting times ranged from 10 to 50 min and were lower for cements with lower L/P content. Calcium silicate hydrate was the principal phase formed during the hydration process of the cements. The cement exhibited a moderate degradation and could induce carbonated hydroxyapatite formation on its surface and into the pores. The cell attachment test showed that the -Ca2SiO4 solid solution supported human adipose stem cells adhesion and spreading, and the cells established close contacts with the cement after 24 h of culture. The novel -C2Sss cements might be suitable for potential applications in the biomedical field, preferentially as materials for bone/dental repair.

• 出版日期2014-2