Direct ortho-Selective C-H Functionalization of Carboxybenzyl-Protected Arylalkylamines via Ir(III)-Catalyzed C-H Activation

作者：Li, Guobao; Hu, Jundie; Zeng, Runsheng^*; Shio, Da-Qing; Zhao, Yingsheng^*

来源：Organic Letters, 2018, 20(8): 2454-2458.

DOI：10.1021/acs.orglett.8b00797

• ORTHO-C(SP(2))-H BONDS
• ORTHO-ALKYNYLATION
• C(SP(3))-H BONDS
• AMIDATION
• ARYLATION
• C(SP(2))-H
• AMINATION
• ARENES
• MILD
• ALKENYLATION

A convenient and practical approach to synthesize ortho-alkynylated arylalkylamines through ortho-selective C-H functionalization has been developed using Cbz-amide as the directing group and Ir(III) as the catalyst. Various substrates were well tolerated, affording the corresponding products in moderate to good yields. Moreover, preliminary mechanistic study revealed the role of the amide as the coordination center to cooperate with the Ir(III) complex during C-H activation. Development of this Cbz-amide-promoted C-Ar-H functionalization offers a practical approach with potential applications in organic synthesis.

• 出版日期2018-4-20
• 单位苏州大学